The Cold existed on the border between universes. It seeped out through the centre of a Time Lord space warship, poised to destroy pre-spacefaring Earth if the enemy gained too much ground. Faction Paradox created the Remote colony Anathema on the warship.
If a subject was introduced to the Cold they would be taken out of the physical universe and held in stasis with no ill effects.
In 1996, the warship was finally close enough to Earth for the Remote to travel there. They sold canisters of the Cold at a weapons convention. Some was used on Fitz Kreiner, who was released on Ordifica six hundred years later, when the Remote first discovered it.