Scarlette (originally Isobel) was the owner of a brothel on Henrietta Street in the 18th century.

She was born in 1762, the year that Mary Culver slit her own throat. (PROSE: The Adventuress of Henrietta Street) As a young girl, Isobel assisted Snaddon in caring for George III's royal menagerie. When Mother Francesca of Faction Paradox caught her eavesdropping on a conversation about the War, she helped her to ride the King's woolly mammoth. (COMIC: Political Animals) After Mayakatula escaped her cell, Isobel confronted her in a church, and Mayakatula taught her the ways of the Mayakai, one of the groups who had "inherited" the knowledge of the mysterious elementals following their destruction. (COMIC: Bêtes Noires & Dark Horses, PROSE: The Adventuress of Henrietta Street)

Using this training, Scarlette aided the Doctor in coordinating a defence against a new danger from outside the conscious universe. She married the Doctor in a ceremony arranged to symbolically bind the Doctor to Earth and allow him to participate in its defence; however, over their time together, the two actually fell in love, and the ceremony developed a deeper meaning for both parties. However, recognising that the Doctor's feelings for her would keep him on Earth when he needed to continue traveling to other worlds that needed his help, Scarlette faked her death once the crisis was over. (PROSE: The Adventuress of Henrietta Street)

Sabbath later referred to Scarlette as the only woman the Doctor ever got close to. (PROSE: Camera Obscura)

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